Research field
Pharmacology
Pharmacology studies how drugs interact with biological systems, encompassing the molecular mechanisms of drug action at receptors, the kinetic and dynamic processes governing drug disposition, and the population-level variation in drug response driven by genetics. Structural studies of G protein-coupled receptors in active and inactive states have transformed rational drug design for cardiovascular, CNS, and metabolic disease targets. Pharmacogenomics integrates genomic information to predict individual drug response, moving towards precision prescribing based on a patient genetic makeup. Physiologically based pharmacokinetic models simulate drug disposition across species and special populations from first principles. Pharmacology bridges basic science and clinical medicine, informing drug approval and post-market surveillance of safety signals.
Top institutions
University College London
Karolinska Institutet
Johns Hopkins University
University of Michigan
University of Basel
Subfields
Key technologies
GPCR Structural Biology
Patch-Clamp Electrophysiology
PBPK Modeling
cryo-EM Drug Binding
PET Receptor Occupancy
Researchers in Pharmacology
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