Research field
Organoid Biology
Organoid biology creates three-dimensional, self-organizing miniaturized organ-like structures from stem cells that recapitulate the architecture and function of human organs in culture. Intestinal organoids preserve patient-specific epithelial genetics for personalized drug response testing and cystic fibrosis mutation correction studies. Cerebral organoids model early human brain development and neurodevelopmental disorders inaccessible to animal models. Tumor-derived organoids capture the heterogeneity of patient biopsies and predict chemotherapy response in clinical trials. Advances in vascularization and immune cell co-culture are addressing a key limitation: the absence of blood supply and systemic interactions in classical organoid systems. Organoids are reshaping drug development, disease modeling, and regenerative medicine.
Top institutions
Hubrecht Institute
Cincinnati Childrens Hospital
Hans Clevers Lab
Weill Cornell Medicine
University of Cambridge
Subfields
Key technologies
3D Matrigel Culture
Air-Liquid Interface Culture
Single-Cell Transcriptomics
CRISPR Perturbation Screens
Microfluidic Organoid-on-Chip
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