Bioprocessing & Upstream Manufacturing

Repligen Corporation

Repligen Corporation, headquartered in Waltham, Massachusetts, is a leading provider of bioprocess filtration, chromatography, and analytical technologies for the manufacture of biologics including monoclonal antibodies, gene therapies, and mRNA vaccines. Its product lines include ATF (Alternating Tangential Flow) cell-retention systems, single-use hollow-fibre bioreactors, protein A resin ligands, and XCell ATF systems that are integral to perfusion bioprocessing. Repligen collaborates with biotechnology and academic bioprocess-engineering groups on continuous bioprocessing, viral-vector production, and lipid-nanoparticle manufacture. The company's OPUS pre-packed chromatography columns are used in clinical-scale purification at academic medical centres running gene-therapy trials. Repligen's analytical instruments (REFLX and SRT single-use filtration) are increasingly used in academic labs studying membrane fouling and tangential-flow filtration phenomena.